The Powershell script below can be used to set the out-of-office auto-reply message for a specific mailbox from a workstation.
# start remote session from workstation $s = New-PSSession -ConfigurationName Microsoft.Exchange -ConnectionUri http://MyExchangeServer/PowerShell/ -Authentication Kerberos Import-PSSession $s # enable Out of Office reply $mbox = 'JCDough' $internal = 'I am currently out of office and unable to return phone calls and emails. Please contact your TAS Specialist and or someone else on the TAS team with any immediate concerns. Thanks!' $external = 'I am currently out of office and unable to return phone calls and emails. Please contact your account manager with any immediate concerns and we will make sure your taken care of. Thanks!' Set-MailboxAutoReplyConfiguration $mbox -AutoReplyState enabled -ExternalAudience all -InternalMessage $internal -ExternalMessage $external # Disable Out of Office reply $mbox = 'JCDough' Set-MailboxAutoReplyConfiguration $mbox -AutoReplyState disabled